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Tirzepatide has a plasma half-life of approximately 5 days (120 hours), supporting once-weekly subcutaneous dosing
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Although CPT1A and CPT1B exhibit considerable sequence similarity, the sensitivity of these two enzymes to their physiological inhibitor, malonyl-CoA, differs greatly (CPT1A has a ten-fold higher Ki for malonyl-CoA) 39,40
The peptide was added to the culture medium and refreshed every three days
Srinivas SR, Prasad PD, Umapathy NS, Ganapathy V, Shekhawat PS
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