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Most protocols run weekly, with some clinics using twice-weekly or every-other-week schedules depending on the formulation and the patient
Together with HSP70 and HSP90, sHSPs form an integrated chaperone network that buffers neurons against proteotoxic stress, delays aggregate formation, and promotes clearance of damaged proteins
10.1038/335547a0 141 YuX.HeZ.WangZ.KeS.WangH.WangQ.et al (2024)
Critically, and this is the connection to NAD+ that matters for stacking, according to the foundational 2016 PMC paper by Lee et al
Scientists are studying them as potential treatments for addiction and dementia
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