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60 In cancer cells, complex II activation via METTL1-mediated m7G tRNA modification and SDHAF4 upregulation drives mitochondrial OXPHOS and gastric cancer progression, 61 whereas complex II activity is downregulated by evolutionarily conserved selenoprotein O (SELENOO)-mediated AMPylation of SDHA, promoting melanoma metastasis through modulation of oxidative stress responses

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Dapagliflozin in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the DELIVER trial