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In the elderly, dry mouth is a great concern as it makes chewing, swallowing and digestion difficult and this can lead to poor nutritional deficiencies and even pneumonia
Published clinical evidence includes a Phase 1b multiple-ascending-dose trial reported by Enebo and colleagues (Lancet, 2021) and a Phase 2 trial in type 2 diabetes reported by Frias and colleagues (Lancet, 2023), both studying cagrilintide together with semaglutide
Suspected side effects from any medicine, including trial drugs, should be reported via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk
Because of its structural differences, IGF-1 LR3 shows reduced affinity for certain IGF-binding proteins (IGFBPs) in vitro, enabling researchers to study more sustained receptor engagement and downstream signaling under controlled conditions
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