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OCTN2 ( SLC22A5 ) is not only a Na + -independent organic cation transporter but also a Na + -dependent and high-affinity carnitine transporter, which is widely distributed in various tissues such as kidney, intestine, placenta, breast, liver, heart, testis, skeletal muscle and bloodbrain barrier [161]

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For example, the ingestion of trimethylamine-containing (TMA-containing) dietary nutrients enriched in animal products such as choline, phosphatidylcholine, and l-carnitine can serve as precursor for the ultimate generation of an atherogenic metabolite, trimethylamine N -oxide (TMAO), via a metaorganismal pathway involving initial gut microbial formation of TMA, followed by host hepatic conversion of TMA into TMAO (48)

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