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Cifarelli, V
Another mode of GSH depletion occurs through GSH transferase-mediated reactions where DEM, an electrophilic reagent and a mildly reactive alpha, unsaturated carbonyl compound conjugates with GSH which is catalyzed by GSH transferase which leads to the formation of hydrophilic GSH conjugates and causes rapid depletion of GSH [11, 92, 27] [90]
Metabolism: It is rapidly degraded by peptidases in pharma and tissue
Initial data from this trial is expected in the first half of 2025.
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