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11,12 Notably, the potential neuroprotective properties of GLP-1 RAs extend to conditions like Alzheimer disease (AD) and Parkinson disease by ameliorating motor impairment and curtailing oxidative stress, inflammation, and apoptosis

The SOD2 protein is located within the mitochondrial matrix and functions as a homotetramer

Rodriguez, PhD MPH Truveta, Inc, Bellevue, WA, Samuel Gratzl, PhD Truveta, Inc , Bellevue, WA, Charlotte Baker, DrPH MPH CPH Truveta, Inc , Bellevue, WA, Duy Do, PhD Truveta, Inc , Bellevue, WA, Nicholas Stucky, MD PhD Truveta, Inc , Bellevue, WA Increasing demand for GLP-1 RA medications has led to global shortages, which could result in patients switching to other medications, or discontinuing their treatment completely

And his willingness to explore an unusual biological systemlizard venompositioned him to make a discovery that more conventional researchers missed