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Recently, there has been heightened interest in how the activated GLP-1R is trafficked between different endomembrane compartments, controlling the spatial origin and duration of intracellular signals
The increase in gastrointestinal problems has been well-documented, and the rise in low blood pressure and kidney stones is probably because GLP-1 patients could be somewhat fluid-depleted from not eating or drinking as much, said Dr Stephen ORahilly, co-director of the Institute of Metabolic Science at the University of Cambridge
However, these parameters derive entirely from animal studies, and optimal human administration strategies remain undefined
3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Du et al., 2022
however, it is specifically approved for type 2 diabetes
