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[9] [12] Cardiovascular disorders: Caution should be exercised when administering sildenafil to individuals with known cardiac disorders such as arrhythmias, aortic stenosis, heart failure, and myocardial infarction, among others
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However, advances in whole exome sequencing and bioinformatics have been used to identify individual mutations, predict novel antigens and their peptide ligands, and assess peptide-HLA affinity
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