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The right maintenance dose is the one you can sustain long-term with acceptable tolerability and continued progress
EVOKE+ demonstrated that high-dose oral semaglutide engaged Alzheimers biology, producing favorable shifts in biomarkers of neurodegeneration and neuroinflammation, even though those changes did not translate into measurable clinical benefit over the trial period
As their use has expanded dramatically in recent years, questions about long-term safety, including potential cancer risk, have become increasingly important for both patients and clinicians
Public health minister Sharon Hodgson acknowledged this issue but told the committee that she did not know if conversations had started with the medicines regulator about dealing with rising demand in the counterfeit market
Forman JP, Rimm EB, Stampfer MJ, Curhan GC
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