The Injection (Subcutaneous) - Dosing: Once weekly - Bioavailability: ~100% (bypasses GI tract) - Weight loss in trials: Up to 22% at 36 weeks - Best for: Patients seeking maximum efficacy, comfortable with self-injection The Pill (Oral) - Dosing: Once daily (taken on an empty stomach, similar to Rybelsus) - Bioavailability: Lower than SC (relies on SNAC absorption technology) - Weight loss in trials: Up to 13.1% at 12 weeks (Phase 1 short duration) - Best for: Injection-averse patients, early treatment, maintenance, broader access The oral formulation will almost certainly deliver less weight loss than the subcutaneous version at equivalent treatment durations
In trials involving 176 participants across four randomized controlled studies, liraglutide was used in 58% of cases (103 participants), while semaglutide was used in 13% (23 participants)
For many clients, this is the point in the year when it becomes easier to make a confident, informed decision about what their body needs heading into winter
Mounjaro is approved for diabetes, while Zepbound is approved for weight loss
Diabetes, Obesity and Metabolism, 25(1), 1-10