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MT-II activation at these receptors reduces food intake in animal models, and appetite suppression is a commonly reported effect in human use

This is the central challenge for any patch-based claim

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A drug can be metabolized in the gut wall (eg, by the CYP3A4 enzyme system) or even in the portal blood, but most commonly it is the liver that is responsible for metabolism before the drug reaches the systemic circulation

However, like any medical treatment, it should be performed after proper consultation and evaluation