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El GLP-1 derivado del cerebro es producido principalmente en neuronas del rea caudal del ncleo del tracto solitario, que proyectan sus terminaciones nerviosas hacia el ncleo paraventricular y estimula la secrecin de la CRH para promover un efecto anorexgeno 23

In summary, GLP-1 and its analogues appear to exert multiple important actions in brain, liver, muscle and fat in addition to its main action of stimulating insulin secretion

Consistency matters enormously with GLP-1 therapy because steady blood levels produce better results than erratic dosing