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In fact, that is one reason reinjury occurs

Summary Cellular senescence, marked by irreversible cell cycle arrest and the secretion of proinflammatory factors, contributes to aging and cancer recurrence

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Neuropathy or neurological disease: Although evidence is mixed, injections are often given when deficiency is linked to nerve pain or cognitive symptoms

This is clinically significant for drugs with narrow therapeutic windows (thyroid hormone, anticoagulants, immunosuppressants)