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Retrieved 23 July 2021

A preclinical safety evaluation of BPC-157 published in Regulatory Toxicology and Pharmacology found this peptide to have a favorable safety profile

The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

2i,j), suggesting that this response is independent of oncogenic driver mutation and culture conditions 22

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