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As a matter of fact, n in Table 6 went all the way from 1 (g(28,1) in Table 6) to 7 g(28,7) in Table 6, in comparison with the length (28) of the backbone of semaglutide, while the structural modeling (Modeller [44]) and and K d calculations (Prodigy [45, 46]) were performed completely only for g(28,1) (as in Table 6), as from Table 6, it is quite clear that the size of the computational task is too huge even for a high performance computing facility

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For 6-minute walk tests, however, a 20-m difference has been described by McDermott et al 36 as clinically important

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