Digestion of dietary phospholipids takes place in the duodenum as well via the action of pancreatic phospholipase A 2 (PLA 2 ), yielding free fatty acids and lysophospholipids
Treatment with GLP1RAs resulted in unaffected or reduced C max and delayed t max of drugs with high solubility and permeability (warfarin, contraceptive pills, acetaminophen), drugs with high solubility and low permeability (angiotensin converting enzyme inhibitors), drugs with low solubility and high permeability (statins) and drugs with low solubility and permeability (digoxin)
Side Effects & What to Expect Because both medications modulate hormonal and digestive pathways, side-effects tend to overlap: Common with Tirzepatide: nausea, digestive changes (GI symptoms), reduced appetite, slower digestion
Companies work around this by using complementary proteins, which involve combining two or more protein sources to obtain all essential amino acids in their supplement 11
Prebiotic fibers , special fermentable fibers found in foods like garlic, onions, green bananas, and cooked and cooled potatoes, go a step further