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The experimental animal, properly identified by its weight number, should be securely restrained by an assistant, positioning the animal with its head downward and abdomen upward

Plaintiffs in this MDL allege that GLP-1 drugs increased the risk of NAION and that manufacturers failed to adequately warn patients and health care providers about this potential danger

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Importantly, the presence of side effects may also serve as a clinical cue that the appetite-regulating mechanism is active , though any severe or persistent symptoms warrant reevaluation of dose or co-therapy timing