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33 Renal Effects of GLP-1RAs in Patients With Diabetes Mellitus SAFEGUARD was a randomized placebo-controlled parallel group trial of 56 patients with T2D on exenatide, showing no change in effective renal plasma flow, measured by para-aminohippurate clearance, over 12 weeks (NCT01744236)

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GLP-1 effects include slowing gastric emptying, increasing satiety, as well as cardioprotective effects ( via inducing osteoblast activity and reduction of bone resorption via inhibition of osteoclasts ( Figure 1 )

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