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Both the National Institutes of Health (NIH) and the Institute of Medicine have not established an upper limit for B12 intake, even when doses exceed the daily recommended amounts by thousands of micrograms (source: National Institutes of Health)

The Day-by-Day Breakdown Each MOTS-c cycle consists of exactly 4 injections spread across 20 days, one every 5 days: Why Only 4 Injections

The injection site may be numbed with a local anesthetic to minimize discomfort