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Adding amylin agonism to a dual or triple incretin agonist is mechanistically plausible, but the concern is stacked gastrointestinal burden: adding semaglutide alone pushed GI events from 54.0% to 79.6%, and discontinuations from 2.6% to 5.9%

Oxidative stress from free radicals leads to cell damage and faster cellular degeneration, accelerating the aging process

This inhibition can naturally be thought of as product inhibition, one step removed

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Rights and permissions About this article Cite this article Winther, J., Jakob, U