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Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via G q transducer pathways (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)

The molecule incorporates a C20 fatty diacid moiety linked via a gamma-glutamic acid spacer, which binds to serum albumin and confers the extended 5-day half-life enabling once-weekly dosing

By inhibiting NNMT activity, 5Amino1MQ helps increase cellular energy efficiency, reduce fat cell growth, and accelerate fat metabolism

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