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The full effects build as you titrate to your target maintenance dose, with maximum efficacy reached 4 to 8 weeks after achieving your final dose
Possible Side Effects Spironolactone can cause some common side effects, such as dizziness, nausea, cramps, frequent urination, menstrual irregularities (affecting 7.9%11.85% of users), breast tenderness, fatigue, and headaches
The main aim of drug repositioning is to counteract attrition and rising costs, which, according to Erooms law, have produced a large increase in the number of new drugs entering the pharmaceutical market
That is significantly higher than the Phase 2 numbers, and it likely reflects the higher maintenance doses used in TRIUMPH-4 combined with the longer observation period
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