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References Neeland, I

Here's the math: At steady state on a 1 mg weekly dose, your blood concentration oscillates in a predictable pattern: Peak concentration: approximately 24 to 48 hours after injection Trough concentration: immediately before your next scheduled dose (day 7) The trough is roughly 50% of the peak due to one half-life of elimination When you inject one day early (day 6 instead of day 7), you're dosing when your blood level is at approximately 57% of peak instead of 50%

That said, the human evidence for each pathway remains preliminary

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Beneficiaries who were coded with obesity or overweight and either a prior heart attack (AMI_EVER), prior stroke (STROKE_TIA_EVER), or peripheral arterial disease were coded as being eligible for the new use of Wegovy