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When the tumor volumes reached approximately 100 mm 3 , twenty female BALB/c nude mice bearing 143B tumors were randomly assigned into four groups

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Histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally associated with transcriptional activation, and H2Bub1 epigenetically activates the expression of SLC7A11, but p53 decreases H2Bub1 occupancy on the SLC7A11 gene regulatory region and represses the expression of SLC7A11 during ferroptosis process (Wang et al., 2019f)