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Enzymatic antioxidants are localized in specific subcellular compartments where radicals are frequently generated (mitochondria, peroxisomes or microbodies, cell cytosol) or are present in the systemic circulation
Recently, a randomized, double-blind, placebo-controlled trial in 295 patients with Alzheimers disease found that DHA supplementation (2 grams/day) for 18 months was not effective in slowing cognitive decline (129)
The key monitoring point is whether the side effects (particularly the head rush and hunger response) remain consistent
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