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Weight loss from GLP-1 therapyoften 10-20% of body weightcontributes significantly to any blood pressure improvement observed over weeks to months
Abstract The incretins are gut hormones secreted in response to nutrient/carbohydrate ingestion and act on the pancreatic beta cell to amplify glucose-stimulated insulin secretion
While these are population-level numbers, the principle applies to individuals as well: routine injection visits for non-deficient patients add up in copays, travel time, and appointment scheduling without delivering additional benefit
The combination of these effects makes semaglutide a powerful tool for long-term, non-surgical weight loss
The regulation of NSC proliferation, self-renewal, and differentiation is finely regulated by changes in the surrounding microenvironment, or niche, in which NSCs reside (reviewed in Andreotti et al., 2019)
