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If eventually, the ice packs melt and are no longer cold, semaglutide can be kept at room temperature (up to 86F or 30C) for a limited time (up to 28 days)

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Unopened lyophilized powder is more forgiving and can tolerate brief room-temperature periods, but a reconstituted vial needs consistent refrigeration and should be used within 28 days, the window supported by bacteriostatic water's antimicrobial preservative