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persistent gastrointestinal symptoms beyond 2 weeks after discontinuation
A meal of 200 to 300 calories clears meaningfully faster than one of 700 to 800 calories when gastric emptying is pharmacologically slowed
If none of the domains were classified as high risk but one or more were deemed to have some concerns, the overall risk of bias for that trial was categorised as of some concern
Bottom Line The peptide craze is unfounded
In comparison, tirzepatide's best results were found in a phase 3 trial that showed the drug could lead to a weight loss of up to 20.9% at 72 weeks about 52 pounds for someone starting at 250 pounds
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