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In addition, the released chemokines activate the secretion of other inflammatory mediators from peripheral blood into the site of inflammation and potentiate the cytokine storm (Figure 1)

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Erythropoietin is produced by peritubular capillary endothelial cells in the proximal tubule, and acts by stimulating the production of red blood cells in the bone marrow (Ohana et al

Additionally, high cortisol levels have been shown to reduce SAMe levels, which are crucial components of the methylation pathway