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For systemic anti-aging or cosmetic changes, studies often run for several months to observe measurable changes in biomarkers or skin elasticity

Margulies KB, Anstrom KJ, Hernandez AF, Redfield MM, Shah MR, Braunwald E, Cappola TP

Metal-based nanoparticles are more controllable in terms of particle size, but they are not biodegradable and are often accompanied by toxicity