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Weight regulation is recognized as a complex physiological process influenced by insulin sensitivity, appetite signaling, inflammatory burden, and lifestyle factorsrequiring individualized assessment and clinically guided intervention
Researchers should consult peer-reviewed literature for experimental design guidance
In Caucasian subjects, mean body weight was reduced by 3.6 kg with semaglutide 0.5 mg and 7.5 kg with semaglutide 1.0 mg, versus an increase of 0.7 kg with placebo [estimated treatment difference 4.3 kg ( p 0.05) and 8.3 kg ( p 0.05)] (Supplementary Table S2)
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