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The abdomen (at least 2 inches from the navel), outer thigh, and upper arm are standard rotation sites for subcutaneous GLP-1 receptor agonist injections

Managing gastrointestinal side effects is also crucial to avoid dehydration-related complications, which could exacerbate kidney issues

For example, semaglutide, a once-weekly injectable GLP-1R agonist, resulted in significant weight loss, histological resolution of steatohepatitis and improvements in cardiovascular biomarkers [184], although it did not meet the histological antifibrotic effect threshold or reverse cirrhosis in a separate study [185]

Clinical studies show that patients may lose up to 15% of their body weight over 6 to 12 months with consistent use and lifestyle changes

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