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In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight

Sepesi B, Ye Y, Zhang L, Gu J, Ji L, Antonoff M, Hofstette W, Rice D, Mehran R, Walsh G, Vaporciyan A, Swisher SG , Roth JA, Wu X

PMID: 40225275

The only shelf life that should be followed is the one stated on the IMP label or clinical trial protocol provided by the trial sponsor