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Fatigue shows up early for many patients, and some develop food aversion that goes beyond reduced appetite into not wanting to eat at all, which creates its own nutritional concerns down the line
However, the FDA has received voluntary reports from patients describing emotional numbness, reduced motivation, and depressive symptoms after starting GLP-1 therapy, though causality remains unclear
Protein, soluble and fermentable fiber, and healthy fats can all raise your own GLP-1 a little
Semaglutide heart-protective benefits appear across all BMI ranges and do not depend on weight loss
Meet our doctors Last reviewed: 08 Jun 2025 Sources Obesity treatment, NHS [accessed June 2025] Saxenda, emc [accessed June 2025] Ozempic, emc [accessed June 2025] Wegovy, emc [accessed June 2025] Semaglutide for managing overweight and obesity, NICE [accessed June 2025] Weight loss injections NHS weight loss injections GLP-1 for weight loss Can doctors help with weight loss
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