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Studies have suggested that higher doses might become necessary for significant health advantages, but they should be taken under medical supervision

If you want to switch to beverages that have lower levels of caffeine than coffee, you could consider green tea

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These endogenous gut hormones act on the central nervous system either via the circulation through areas deficient in the bloodbrain barrier, such as the median eminence of the hypothalamus and the area postrema [5] or via receptors of vagal afferents, together with stretch receptors and nutrient chemoreceptors [6]

The warning label on the medication now cautions that the medication may cause intestinal blockage