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Grapes are a source of polyphenols, proanthocyanidins, and resveratrol, all of which modulate oxidative stress and have been studied in a wide range of health conditions, including high blood pressure, cancer, and Alzheimer disease (Pasinetti 2014

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But many times, theyre triggered by outside sources like: Sun exposure (UV radiation) Air pollution Cigarette smoke Toxins and chemicals Stress and poor diet An overload of free radicals sets off something called oxidative stress

The oxidized form of guanine, 8-oxo-2-deoxyguanosine (8-oxo-dG), is a valuable marker of oxidative DNA damage during carcinogenesis (116, 117)

It acts by reoxidising protein disulfide isomerase (PDI), the enzyme catalyzing disulfide formation