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The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
The role of exercise in keto plus GLP-1 outcomes Neither keto nor GLP-1 replaces exercise
Some plans require bariatric surgery candidacy screening before approving GLP-1 therapy, a gatekeeping practice that delays treatment for months
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