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reported that metformin (Met) treatment alleviated ferroptosis in -cells in T2DM patients by increasing GPX4 expression and downregulating ACSL4 expression, whereas RSL3 injection significantly diminished the antiferroptotic effect of Met [84]

Blood specimen collection, hormonal parameter monitoring and genetic testing All blood specimens were obtained from the subjects in the morning after an overnight fast

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The gene responsible for type 1 Bartter encodes the NKCC2 protein (Na + /K + /2 Cl cotransporter 2)

Injection procedures are more complicated with once-weekly medications