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How Wegovy works Wegovy contains semaglutide, a GLP-1 receptor agonist
However, there is evidence that it may also increase LDL cholesterol in some patients, which increases the risk of cardiovascular disease
Variants in FTO , the fat-mass and obesity-associated gene, along with GLP1R (the GLP-1 receptor gene that every GLP-1 compound targets), MC4R (a melanocortin receptor tied to satiety and energy balance), and TCF7L2 (a transcription factor linked to glucose homeostasis) describe the metabolic terrain a clinician is prescribing into
At these microdoses, clients often report: Feeling comfortably full with smaller portions Fewer late-night snack cravings that can stall weight goals More stable, all-day energy without the highs and crashes Clearer focus and reduced brain fog Better control over emotional or stress-related eating Less day-to-day fluctuation in appetite Improved consistency with exercise routines due to steadier energy Feeling more in control of eating choices, rather than food controlling them Microdosing also makes it easier to integrate the medication into a whole-body wellness plan
PMCID: PMC12155186
