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A clinical trial following patients after semaglutide discontinuation found that weight gain began immediately and accelerated over weeks

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5.6 Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues JANUMET XR may increase the risk of hypoglycemia when combined with insulin and/or an insulin secretagogue (e.g., sulfonylurea) [see Adverse Reactions (6)]

DOI: 10.1016/j.mam.2008.05.005 14