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ONC201 Possesses a Benign Safety Profile at Highly Efficacious Doses in Normal Human Cells and Animal Toxicology Studies
To determine the significance of such overexpression, we evaluated the effect of silencing GSTO1 on cancer cell viability
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The prevailing model for NRF2-dependent target gene expression involves the binding of NRF2 to ARE sequences within proximal promoters of specific target genes (Tonelli et al, 2018)
& Peyssonnaux, C
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