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Also affects other pro-angiogenic factors (FGF, angiopoietin)

One day of intranasal UCT-MSC-EXs therapy began in November 2022, and his second 1-day treatment of intranasal UCT-MSC-EXs began in January 2023

Jimnez E, Sol B, Arias B, Mitjans M, Varo C, Reinares M, et al

Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function

At room temperature and physiological pH, unmodified small peptides in solution degrade over days to weeks, not months