tirzepatide surmount 2 SURMOUNT-1 Trial Tirzepatide for the Treatment of

Blocking was performed with 5% BSA

The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 with arginine, which ultimately leads to the formation of an 83 amino acid peptide

Mechanisms of Benefit Weight LossMediated: The predominant proposed mechanism is indirect: weight loss reduces adipose-derived pro-inflammatory cytokine secretion, lowers systemic IL-6, TNF-, and IL-17 levels, improves insulin sensitivity, and reduces the immunological "noise" that drives psoriatic inflammation

These elements work synergistically to enhance the drugs efficacy in reducing body weight and combating obesity

2014;6:263ra158 Romano KA, Vivas EI, Amador-Noguez D, Rey FE, Blaser MJ