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While both are analogues of -MSH, Melanotan 1 is much more selective, primarily targeting the MC1R receptor

This protective effect involves upregulation of antioxidant enzymes and maintenance of mitochondrial membrane potential, indicating Dihexa activates endogenous cellular defense mechanisms that guard against neuronal injury

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[1] Multiple Endocrine Neoplasia syndrome type 2 (MEN2) a genetic condition that predisposes to MTC

The exact mechanism isnt fully understood, but researchers believe the drug affects blood flow to the optic nerve, particularly in patients with existing cardiovascular risk factors