(NIDDK) I also see a second misconception: that success on these medications is purely about eating less. In reality, the reason many patients do better with GLP-1-based treatment is that these medications can change the biology driving overeating, poor fullness signaling, and dysregulated blood sugar
Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis
A., Brands, M., Kootte, R
However, specific exceptions and monitoring requirements apply
Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man