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Acetaminophen also increases both neuronal CYP2E1 enzymatic activity and protein levels, as determined by western blot, leading to neuronal death through mitochondrial-mediated mechanisms that involve cytochrome c release and caspase 3 activation

Disruption of cholesterol efflux by coxib medications and inflammatory processes: link to increased cardiovascular risk

In short: injectable = more direct, possibly stronger acute effect

Life Sciences, provided glutathione and partial financial support for this work