glp 1 and psoriatic arthritis Glucagon-like peptide its receptor agonists for the treatment of rheumatic diseases Exploring the Role of GLP-1

Niedzwiecki, M

In addition to GLP-1R/GCGR dual agonists, a chimeric peptide as dual GLP-1/GIP receptor agonists has been developed, showing enhanced therapeutic potential for obesity and related comorbidities

Intranasal delivery, bypassing the BBB via neural pathways, has emerged as an alternative, particularly effective for peptide-modified or mucoadhesive NPs delivering hydrophilic or biologic agents [63]

When the mitochondrial antioxidant system is damaged and ROS cannot be eliminated from cells, lipid peroxidation is mediated through the Fenton reaction [7, 82]

MOTS-C directly improves mitochondrial function and metabolic efficiency