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Details of the National Institutes of Health-funded study were published this week in a Nature paper titled A brain reward circuit inhibited by next-generation weight-loss drugs in mice. In it, the team reported that they investigated the small-molecule GLP-1s including Eli Lillys recently approved drug orforglipron, also known by the brand name Foundayo, as well as danuglipron, an oral GLP-1 that was being developed by Pfizer until the company decided to discontinue its development in 2025
It binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and secretion of endogenous growth hormone in a natural pulsatile pattern (1)
At our practice, we ensure that any off-label use of Ozempic for weight loss is carefully considered and monitored under the guidance of our experienced healthcare providers
Collecting duct water permeability inhibition by EGF is associated with decreased cAMP, PKA activity, and AQP2 phosphorylation at Ser(269)