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A phase 3 trial comparing retatrutide with tirzepatide in adults with obesity is listed on ClinicalTrials.gov, which should provide more direct comparison data when completed and published 15

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Final Thought Taking semaglutide can be a double-edged sword

Pakistan Journal of Medical Sciences , 29(4), 938942

Both hormones augment insulin secretion in a glucose-dependent manner [4], which is a fail-safe mechanism that minimizes the risk of hypoglycemia even in a situation with excessive secretion of incretin hormones